stem cell treatment for neuropathy reviews

As a novel treatment, stem cell-based therapy is gaining significant attention. Despite significant advances in NP treatment, safe and effective treatment options targeting NP are lacking. NP makes up 20–25% of chronic pain patients, and although it may vary, due to a global dissonance of the definition of NP, a systematic epidemiological review has estimated the prevalence of NP between 3% and 17%. Neuropathic pain (NP) is defined by The International Association for the Study of Pain (IASP) as pain that occurs as a direct consequence of lesion or disease affecting the somatosensory system. The prevalence of chronic pain increases through adult life, and previous estimates of chronic pain in the adult population ranged from 11% to 19%. Chronic pain is defined as pain that persists after healing is, or exists without tissue damage, and usually lasts longer than three months. The physiological response to pain is essential for the body’s risk awareness and risk avoidance. Pain is the body’s response to unpleasant (noxious) stimuli, such as external injury or internal disease. Literature searches were conducted using PubMed to provide an overview of the neuroprotective effects of stem cells with particular emphasis on recent translational research regarding stem cell-based treatment of NP, highlighting its potential as a novel therapeutic approach. In addition, we summarize stem cell mechanisms-including neuromodulation in treating NP. In this review, we briefly introduce NP, current pharmacological and nonpharmacological treatments, and preclinical studies of stem cells to treat NP. A growing number of reports have highlighted the potential of stem cells for treating NP. Therefore, scientists are focusing on the introduction of novel treatment approaches, such as stem cell therapy. Current pharmacological and nonpharmacological approaches can provide long-lasting pain relief to a limited percentage of patients and lack safe and effective treatment options. NP treatment is extremely challenging, due to its complex underlying disease mechanisms.

Its pathogenesis involves a wide range of molecular pathways.

Neuropathic pain (NP) is a complex, debilitating, chronic pain state, heterogeneous in nature and caused by a lesion or disease affecting the somatosensory system.

Stem cell treatment for neuropathy reviews